Selective G Protein Coupling by C-C Chemokine Receptors

Chemokine receptors and other G protein-coupled receptors.

PURPOSE OF REVIEW Class A G protein-coupled receptors (GPCRs), including the chemokine receptors, CCR5 and CXCR4, share a seven transmembrane-spanning alpha-helix architecture that accommodates signal propagation from across biological membranes. CXCR4 and CCR5 are utilized as co-receptors during HIV viral entry and, therefore, crystal structures of GPCRs aid in the understanding of their funct...

Representation Learning for Class C G Protein-Coupled Receptors Classification.

G protein-coupled receptors (GPCRs) are integral cell membrane proteins of relevance for pharmacology. The complete tertiary structure including both extracellular and transmembrane domains has not been determined for any member of class C GPCRs. An alternative way to work on GPCR structural models is the investigation of their functionality through the analysis of their primary structure. For ...

Characterisation of the Family C of G-protein Coupled Receptors

Denne afhandling er af Danmarks Farmaceutiske Højskole antaget til offentligt at forsvares for den farmaceutiske doktorgrad. For Anita, without whose support this would have been much harder. Preface i Preface No Man is an Island. This immortal phrase by John Donne also holds true when it comes to science. Thus the present thesis would not have been possible to write without the many fruitful c...

Gi- and protein kinase C-mediated heterologous potentiation of phospholipase C signaling by G protein-coupled receptors.

We recently reported that activation of the highly efficient phospholipase C (PLC) stimulatory m3 muscarinic acetylcholine receptor (mAChR) can induce a long-lasting Gi-mediated heterologous potentiation of PLC stimulation in human embryonic kidney (HEK) 293 cells, which was accompanied by an increased cellular level of the PLC substrate phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P2]. He...

Epithelial Cells Chemokine Production by Renal Tubular Roles of Toll-Like Receptors in C-C